Association of GDF-15, hs-cTnT and NT-proBNP with coronary artery disease in patients undergoing elective angiography.
Tarek SouaidZiad HijaziVanda BarakettAntoine SarkisZeina KadriGorav BatraJohan LindbäckTony AbdelmassihRabih R AzarPublished in: Future cardiology (2022)
Aim: This study investigated the association between plasma levels of GDF-15, hs-cTnT and NT-proBNP and the presence of coronary artery disease (CAD) in stable patients referred for elective coronary angiography. Methods: The outcome of CAD was defined as an ordinal variable with 3 levels. The association between each biomarker and the outcome was tested using the Winell and Lindbäck method. Results: In unadjusted analysis of 252 patients, GDF-15 and hs-cTnT were associated with the presence and extent of CAD. In multivariate regression analysis including traditional risk factors, this association was no longer significant. Conclusion: NT-proBNP, GDF-15 and hs-cTnT plasma levels do not seem to improve the predictive ability of traditional risk factors for CAD in stable patients referred for coronary angiography.
Keyphrases
- coronary artery disease
- patients undergoing
- end stage renal disease
- risk factors
- ejection fraction
- chronic kidney disease
- newly diagnosed
- percutaneous coronary intervention
- cardiovascular events
- coronary artery bypass grafting
- prognostic factors
- cardiovascular disease
- computed tomography
- heart failure
- type diabetes
- mass spectrometry
- high resolution
- left ventricular
- aortic stenosis
- aortic valve
- data analysis