Native aortic valve regurgitation: TAVR's place in the PANTHEON.
Pradeep NarayanPublished in: Indian journal of thoracic and cardiovascular surgery (2023)
The PANTHEON (Performance of Currently Available traNscaTHEter Aortic Valve Platforms in Inoperable Patients With Pure Aortic regurgitatiON of a native valve) study examined transcatheter aortic valve replacement in patients with severe pure native aortic valve regurgitation. With a real-world dataset from 16 centres in Europe and the USA, the study encompassed 201 patients. The major complications included valve embolization or migration in 12.4%, moderate to severe aortic regurgitation in 9.5% cases and need for permanent pacemaker in 22.3% cases. Self-expanding and balloon-expandable devices demonstrated similar outcomes. Those experiencing valve embolization or migration had higher 1-year adverse event rates.
Keyphrases
- aortic valve
- transcatheter aortic valve replacement
- aortic stenosis
- transcatheter aortic valve implantation
- aortic valve replacement
- end stage renal disease
- ejection fraction
- chronic kidney disease
- newly diagnosed
- early onset
- heart failure
- high intensity
- coronary artery
- skeletal muscle
- pulmonary embolism
- patient reported outcomes
- glycemic control