Share and share alike: the role of Tra1 from the SAGA and NuA4 coactivator complexes.

Alan M C CheungLuis Miguel Díaz-Santín

Published in: Transcription (2018)

SAGA and NuA4 are coactivator complexes required for transcription on chromatin. Although they contain different enzymatic and biochemical activities, both contain the large Tra1 subunit. Recent electron microscopy studies have resolved the complete structure of Tra1 and its integration in SAGA/NuA4, providing important insight into Tra1 function.

Keyphrases

electron microscopy
transcription factor
gene expression
dna damage
genome wide
protein kinase