Seeing the Light: CAR T-cell Targeting of Lambda-restricted B-cell Lymphomas.

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)

CD19-targeted chimeric antigen receptor T cells eliminate both malignant and normal B cells. Targeting immunoglobulin light chains instead of CD19 could preserve half of the normal B cells and provide an alternative target.See related article by Ranganathan et al., p. 5951.

Keyphrases

cancer therapy
single cell
nk cells
drug delivery
cell therapy
stem cells
mesenchymal stem cells
bone marrow