Sevoflurane Preconditioning plus Postconditioning Decreases Inflammatory Response with Hemodynamic Recovery in Experimental Liver Ischemia Reperfusion.
Estela Regina Ramos FigueiraJoel Avancini Rocha-FilhoCinthia LanchotteAna Maria Mendonça CoelhoMauro NakataniEduardo Ryoiti TatebeJonathan Augusto Venceslau LimaCamilla Oliveira MendesBruno Camargo Rocha Paim de AraujoEmilio Elias AbdoLuiz Carneiro D'AlbuquerqueFlávio Henrique Ferreira GalvãoPublished in: Gastroenterology research and practice (2019)
All animals showed a decrease in the mean arterial pressure (MAP) and portal vein blood flow during ischemia. After 4 h of reperfusion, only the SPPoC group had MAP recovery. In both the SPC and SPPoC groups, there was a decrease in the ALT level and an increase in the bicarbonate and potassium serum levels. Only the SPPoC group showed an increase in the arterial blood ionized calcium level and a decrease in the IL-6 level after liver reperfusion. Therefore, this study demonstrated that sevoflurane preconditioning reduces hepatocellular injury and acid-base imbalance in liver ischemia. Furthermore, sevoflurane postconditioning promoted systemic hemodynamic recovery with a decrease in inflammatory response.
Keyphrases
- cerebral ischemia
- inflammatory response
- blood flow
- ischemia reperfusion injury
- subarachnoid hemorrhage
- blood brain barrier
- brain injury
- lipopolysaccharide induced
- lps induced
- acute myocardial infarction
- toll like receptor
- high density
- heart failure
- oxidative stress
- coronary artery disease
- atrial fibrillation
- left ventricular