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In vitro Evaluation of the Antileishmanial and Antischistosomal Activities of p-Coumaric Acid Prenylated Derivatives.

Tatiana M VieiraJúlia G BarcoLucas A L PaulaPaulo C A FelixA N D Jairo Kenupp BastosLizandra Guidi MagalhãesAntônio Eduardo Miller Crotti
Published in: Chemistry & biodiversity (2024)
We have evaluated eight p-coumaric acid prenylated derivatives in vitro for their antileishmanial activity against Leishmania amazonensis promastigotes and their antischistosomal activity against Schistosoma mansoni adult worms. Compound 7 ((E)-3,4-diprenyl-4-isoprenyloxycinnamic alcohol) was the most active against L. amazonensis (IC 50 =45.92 μM) and S. mansoni (IC 50 =64.25 μM). Data indicated that the number of prenyl groups, the presence of hydroxyl at C9, and a single bond between C7 and C8 are important structural features for the antileishmanial activity of p-coumaric acid prenylated derivatives.
Keyphrases
  • structure activity relationship
  • electronic health record
  • machine learning
  • alcohol consumption