Remdesivir Use in the Setting of Severe Renal Impairment: A Theoretical Concern or Real Risk?

Natasha N PettitJennifer PisanoCynthia T NguyenAlison K LewAniruddha HazraRenslow ShererKathleen M Mullane

Published in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2021)

RDV AEs occurred infrequently and overall were not significantly different between those with and without SRI. While more of patients with SRI experienced SCr elevations, 3 (75%) patients had acute kidney injury prior to RDV. The use of RDV in this small series of patients with SRI appeared to be relatively safe, and the potential benefit outweighed the theoretical risk of liver or renal toxicity. Additional studies are needed to confirm this finding.

Keyphrases

acute kidney injury
end stage renal disease
ejection fraction
newly diagnosed
prognostic factors
peritoneal dialysis
cardiac surgery
risk assessment