NODDI in gray matter is a sensitive marker of aging and early AD changes.

Xi YuScott A PrzybelskiRobert I ReidTimothy G LesnickSheelakumari RaghavanJonathan Graff-RadfordVal J LoweKejal KantarciDavid S KnopmanRonald C PetersenClifford R JackPrashanthi Vemuri

Published in: Alzheimer's & dementia (Amsterdam, Netherlands) (2024)

Neurite orientation dispersion and density imaging can serve as an effective brain health biomarker for aging and early Alzheimer's disease (AD).Free water fraction has higher sensitivity to normal brain aging.Free water fraction has stronger associations with early AD and regional tau deposition.

Keyphrases

healthcare
white matter
resting state
mental health
multiple sclerosis
cerebral ischemia
climate change