Proteomic biomarkers for survival in systemic sclerosis-associated pulmonary hypertension.

Valentine MismettiXavier DelavenneDavid MontaniSouad BezzeghoudOlivier DelezaySophie HodinDavid LaunaySylvain Marchand-AdamHilario NunesEdouard OllierMartine Reynaud-GaubertJean PastreJulie TracletSébastien QuetantSabrina ZeghmarLaurent BertolettiVincent Cottin

Published in: Respiratory research (2023)

The prognosis of SSc-PH-ILD patients is poor. This proteomic approach found 7 plasma proteins (involved in haemostasis and fibrosis pathways) associated with survival. These potential biomarkers may be good candidates to prognostic enrichment.

Keyphrases

systemic sclerosis
interstitial lung disease
pulmonary hypertension
ejection fraction
newly diagnosed
prognostic factors
free survival
pulmonary artery