Association between Vascular Inflammation and Inflammation in Adipose Tissue, Spleen, and Bone Marrow in Patients with Psoriasis.
Hannah KaiserAmanda Kvist-HansenMartin KrakauerPeter Michael GørtzKristoffer Mads Aaris HenningsenXing WangChristine BeckerClaus ZachariaeLone SkovPeter Riis HansenPublished in: Life (Basel, Switzerland) (2021)
Psoriasis is associated with atherosclerotic cardiovascular disease (CVD) with significant overlap of inflammatory pathways. A link between vascular inflammation and inflammation in multiple adipose tissue types, spleen, and bone marrow may exist. Therefore, we investigated these associations using 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG-PET/CT) in patients with psoriasis (n = 83) where half had established CVD. Carotid ultrasound imaging was also performed. Inflammation was measured by FDG uptake in the aorta, visceral- (VAT), subcutaneous- (SAT), and pericardial (PAT) adipose tissues, and spleen and bone marrow, respectively. Vascular inflammation was associated with FDG uptakes in all adipose tissues, including VAT (β = 0.26; p < 0.001), SAT (β = 0.28; p < 0.001), PAT (β = 0.24; p < 0.001), spleen (β = 1.35; p = 0.001), and bone marrow (β = 1.14; p < 0.001). Adjustments for age, sex, body mass index, and high sensitivity C-reactive protein did not change the results. These associations were generally preserved in the patients without prior CVD. No associations were observed between vascular inflammation and carotid intima-media thickness or presence of carotid plaques, respectively. The results suggest an inflammatory link between vascular and adipose tissues, spleen, and bone marrow in patients with psoriasis.
Keyphrases
- bone marrow
- positron emission tomography
- oxidative stress
- computed tomography
- adipose tissue
- mesenchymal stem cells
- cardiovascular disease
- insulin resistance
- pet ct
- end stage renal disease
- gene expression
- pet imaging
- chronic kidney disease
- type diabetes
- ejection fraction
- magnetic resonance imaging
- high fat diet
- peritoneal dialysis
- atopic dermatitis
- newly diagnosed
- high resolution
- cardiovascular risk factors
- patient reported outcomes
- patient reported
- pulmonary hypertension
- contrast enhanced
- single molecule