Multi-site tumor sampling highlights molecular intra-tumor heterogeneity in malignant pleural mesothelioma.

Clément MeillerFrançois MontagneTheo Z HirschStefano CarusoJulien de WolfQuentin BayardJean-Baptiste AssiéLéa MeunierYuna BlumLisa QuetelLaure GibaultEcaterina PintilieCécile BadoualSarah HumezFrançoise Galateau-SalléMarie-Christine CopinEric LetouzéArnaud ScherpereelJessica Zucman-RossiFrançoise Le Pimpec-BarthesMarie-Claude JaurandDidier Jean

Published in: Genome medicine (2021)

This comprehensive analysis reveals patient-dependent spatial intra-tumor heterogeneity at the genetic, transcriptomic, and epigenetic levels and in the immune landscape of the tumor microenvironment. Results support the need for multi-sampling for the implementation of molecular-based precision medicine.

Keyphrases

single cell
primary care
dna methylation
gene expression
rna seq
quality improvement