The effects of the MTHFR 677C>T (rs1801133) genetic variant on susceptibility and disability worsening in multiple sclerosis patients are mediated by homocysteine.

Claudia Mara RibeiroSayonara Rangel OliveiraTamires FlauzinoDaniela Frizon AlfieriAndrea Name Colado SimãoMarcell Alysson Batisti LozovoyMichael MaesEdna Maria Vissoci Reiche

Published in: Multiple sclerosis and related disorders (2024)

The MTHFR 677C>T variant has an indirect effect on the increase in disability in patients with MS, which also depends on factors such as age, sex, ad folate status.

Keyphrases

multiple sclerosis
end stage renal disease
ejection fraction
newly diagnosed
white matter
chronic kidney disease
prognostic factors
peritoneal dialysis
genome wide
dna methylation
patient reported outcomes