Intronic Cis-Element DR8 in hTERT Is Bound by Splicing Factor SF3B4 and Regulates hTERT Splicing in Non-Small Cell Lung Cancer.

Aaron L SlusherJeongjin J KimMark RibickJesse Pollens-VoigtArmand BankheadPhillip L PalmbosAndrew T Ludlow

Published in: Molecular cancer research : MCR (2022)

Manipulation of a core spliceosome protein reduces telomerase/hTERT splicing in lung cancer cells and results in slowed cancer cell growth and cell death, revealing a potential therapeutic strategy.

Keyphrases

cell death
papillary thyroid
squamous cell carcinoma
cell cycle arrest
editorial comment
cell proliferation
signaling pathway