Moringa oleifera Leaves Extract Ameliorates Doxorubicin-Induced Cardiotoxicity via Its Mitochondrial Biogenesis Modulatory Activity in Rats.

Cyntia Gracesella PatintinganMelva LouisaVetnizah JuniantitoWawaimuli ArozalSilmi HanifahSeptelia Inawati WanandiRajarajan Thandavarayan

Published in: Journal of experimental pharmacology (2023)

leaves extract ameliorates doxorubicin-induced cardiotoxicity by reducing apoptosis and restoring gene expression of PGC-1α and Nrf2, a key regulator in mitochondrial biogenesis.

Keyphrases

oxidative stress
diabetic rats
gene expression
high glucose
drug delivery
mouse model
dna methylation
skeletal muscle
cancer therapy
drug induced
cell death
endothelial cells
anti inflammatory
transcription factor
cell cycle arrest
cell proliferation
signaling pathway
essential oil
stress induced