Butyrate Enhances Desensitization Induced by Oral Immunotherapy in Cow's Milk Allergic Mice.
Marlotte M VonkBart R J BlokhuisMara A P DiksLaura WagenaarJoost J SmitRaymond H H PietersJohan GarssenLéon M J KnippelsBetty C A M van EschPublished in: Mediators of inflammation (2019)
Butyrate supplementation enhanced OIT-induced desensitization of basophils and mast cells and Treg functionality. Only OIT + FOS treatment induced potential microbial alterations, shown by increased butyrate levels in cecum content. Both butyrate and FOS are promising candidates to improve OIT efficacy in human studies to treat food allergies.