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Plasmonic Nanopores for Single-Molecule Detection and Manipulation: Toward Sequencing Applications.

Denis GaroliHirohito YamazakiNicolò MaccaferriMeni Wanunu
Published in: Nano letters (2019)
Solid-state nanopore-based sensors are promising platforms for next-generation sequencing technologies, featuring label-free single-molecule sensitivity, rapid detection, and low-cost manufacturing. In recent years, solid-state nanopores have been explored due to their miscellaneous fabrication methods and their use in a wide range of sensing applications. Here, we highlight a novel family of solid-state nanopores which have recently appeared, namely plasmonic nanopores. The use of plasmonic nanopores to engineer electromagnetic fields around a nanopore sensor allows for enhanced optical spectroscopies, local control over temperature, thermophoresis of molecules and ions to/from the sensor, and trapping of entities. This Mini Review offers a comprehensive understanding of the current state-of-the-art plasmonic nanopores for single-molecule detection and biomolecular sequencing applications and discusses the latest advances and future perspectives on plasmonic nanopore-based technologies.
Keyphrases
  • single molecule
  • solid state
  • label free
  • low cost
  • loop mediated isothermal amplification
  • atomic force microscopy
  • living cells
  • single cell
  • real time pcr
  • high resolution
  • high frequency
  • gene expression
  • dna methylation