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Melatonin inhibits NaIO 3 -induced ARPE-19 cell apoptosis via suppression of HIF-1α/BNIP3-LC3B/mitophagy signaling.

Kai WangYong-Syuan ChenHsiang-Wen ChienHui-Ling ChiouShun-Fa YangYi-Hsien Hsieh
Published in: Cell & bioscience (2022)
-induced mitophagy of ARPE-19 cells via reduction in ROS-mediated HIF-1α targeted BNIP3/LC3B signaling in vitro and in vivo. Melatonin may be a potential therapeutic drug in the treatment of AMD.
Keyphrases
  • high glucose
  • diabetic rats
  • endothelial cells
  • drug induced
  • cell death
  • mass spectrometry
  • cell cycle arrest
  • nlrp inflammasome
  • oxidative stress
  • cancer therapy
  • signaling pathway
  • reactive oxygen species
  • adverse drug