Tumor-derived GCSF Alters Tumor and Systemic Immune System Cell Subset Composition and Signaling.

Israel Matos Maunish Barvalia Manreet K Chehal A Gordon Robertson Iva Kulic Jessica A F D Silva Abhinandan Ranganathan Amy Short Yu-Hsuan Huang Erin Long John J Priatel Salim Dhanji Brad H Nelson Danielle L Krebs Kenneth W Harder

Published in: Cancer research communications (2023)

Tumor-derived GCSF leads to systemic immune population changes. GCSF blockade restores immune populations, improves immunotherapy, and reduces tumor size, paralleling human colorectal cancer data. GCSF inhibition may synergize with current immunotherapies to treat GCSF-secreting tumors.

Keyphrases

stem cells
single cell
machine learning
electronic health record
cell therapy
bone marrow
artificial intelligence