TCRβ repertoire of memory T cell reveals potential role for Escherichia coli in the pathogenesis of primary biliary cholangitis.

Xianliang HouYida YangJianing ChenHongyu JiaPing ZengLongxian LvYingfeng LuXiangdong LiuHongyan Diao

Published in: Liver international : official journal of the International Association for the Study of the Liver (2019)

Our findings comprehensively revealed the TCRβ repertoire characterization of PBC patients, and provided a TCR molecular basis to understand the mechanism of cross-recognition between human PDC-E2 and E coli PDC-E2, and the imbalance of immune tolerance in PBC.

Keyphrases

escherichia coli
regulatory t cells
end stage renal disease
endothelial cells
ejection fraction
chronic kidney disease
newly diagnosed
peritoneal dialysis
prognostic factors
cystic fibrosis
induced pluripotent stem cells
multidrug resistant