A new liver regeneration molecular mechanism involving hepatic stellate cells, Kupffer cells, and glucose-regulated protein 78 as a new hepatotrophic factor.
Kei HagiwaraNorifumi HarimotoTakahiro YamanakaNorihiro IshiiTakehiko YokoboriMariko TsukagoshiAkira WatanabeKenichiro ArakiTomoharu YoshizumiKen ShirabePublished in: Journal of hepato-biliary-pancreatic sciences (2022)
The M2BPGi-activated KCs secrete GRP78, which facilitates liver regeneration and improves the survival in a lethal mice model. Our data suggest that the new hepatotrophic factor GRP78 may be a promising therapeutic tool for lethal liver failure.
Keyphrases
- induced apoptosis
- liver failure
- endoplasmic reticulum stress
- stem cells
- cell cycle arrest
- hepatitis b virus
- signaling pathway
- type diabetes
- transcription factor
- metabolic syndrome
- adipose tissue
- machine learning
- big data
- blood pressure
- electronic health record
- small molecule
- cell proliferation
- free survival
- insulin resistance
- protein protein
- wound healing
- deep learning
- pi k akt
- high fat diet induced