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Abnormal MGMT Promoter Methylation in Gastrointestinal Stromal Tumors: Genetic Susceptibility and Association with Clinical Outcome.

Liping LouWendi ZhangJun LiYu Wang
Published in: Cancer management and research (2020)
MGMT promoter methylation is particularly frequent in SDH-deficient GISTs and in WT GISTs possessing an epithelioid/mixed phenotype, and knowledge of this methylation status may offer a novel potential therapeutic option for WT GISTs.
Keyphrases
  • dna methylation
  • genome wide
  • gene expression
  • transcription factor
  • healthcare
  • copy number