Topical Delivery of Rapamycin by Means of Microenvironment-Sensitive Core-Multi-Shell Nanocarriers: Assessment of Anti-Inflammatory Activity in an ex vivo Skin/T Cell Co-Culture Model.

Fiorenza Rancan Xiao Guo Keerthana Rajes Polytimi SidiropoulouFatemeh ZabihiLuisa HoffmannSabrina HadamUlrike Blume-PeytaviEckart RühlRainer HaagAnnika Vogt

Published in: International journal of nanomedicine (2021)

Overall, our results demonstrate that nanocarriers addressing features of diseased skin are promising approaches to improve the topical delivery of macrolide drugs.

Keyphrases

wound healing
drug delivery
soft tissue
cancer therapy
drug release
stem cells
drug induced