Copy number alteration is an independent prognostic biomarker in triple-negative breast cancer patients.

Masayuki NagahashiYiWei LingChie ToshikawaTetsu HayashidaYuko KitagawaManabu FutamuraTakashi KuwayamaSeigo NakamuraHideko YamauchiTeruo YamauchiKoji KanekoChizuko KanbayashiNobuaki SatoJunko TsuchidaKazuki MoroMasato NakajimaYoshifumi ShimadaHiroshi IchikawaStephen LyleYasuo MiyoshiKazuaki TakabeShujiro OkudaToshifumi Wakai

Published in: Breast cancer (Tokyo, Japan) (2023)

We revealed that CNA, but not TMB, is significantly associated with DFS and OS in TNBC patients. The combination of CNA-high and TP53 alterations may be a promising biomarker that can inform beyond standard clinicopathologic factors to identify a subgroup of TNBC patients with significantly worse prognosis.

Keyphrases

end stage renal disease
copy number
chronic kidney disease
newly diagnosed
ejection fraction
mitochondrial dna
prognostic factors
genome wide
clinical trial
patient reported outcomes
placebo controlled