Translational profiling identifies sex-specific metabolic and epigenetic reprogramming of cortical microglia/macrophages in APPPS1-21 mice with an antibiotic-perturbed-microbiome.
Shabana M ShaikYajun CaoJoseph V GogolaHemraj B DodiyaXulun ZhangHejer BoutejWeinong HanJasna KrizSangram S SisodiaPublished in: Molecular neurodegeneration (2023)
Our studies provide the first snapshot of the translational state of microglial/macrophage cells in a mouse model of Aβ amyloidosis that was subject to ABX treatment. ABX-mediated changes resulted in metabolic reprogramming of microglial phenotypes to modulate immune responses and amyloid clearance in a sex-specific manner. This microglial plasticity to support neuro-energetic homeostasis for its function based on sex paves the path for therapeutic modulation of immunometabolism for neurodegeneration.
Keyphrases
- inflammatory response
- neuropathic pain
- lipopolysaccharide induced
- lps induced
- mouse model
- immune response
- induced apoptosis
- toll like receptor
- cell cycle arrest
- gene expression
- spinal cord
- dna methylation
- spinal cord injury
- adipose tissue
- genome wide
- dendritic cells
- single cell
- multiple myeloma
- metabolic syndrome
- insulin resistance