Tadpole-Like Carbon Nanotube with Fe Nanoparticle Encapsulated at the Head and Zn Single-Atom Anchored on the Body: One-Pot Carbonization for Tetramodal Synergistic Cancer Therapy.
Mengmeng ZhangMingzhu LuYimin GongYannan YangJunfei SongJianing LiZhenxia ChenYun LingYaming ZhouPublished in: Small (Weinheim an der Bergstrasse, Germany) (2024)
Precise integration of diverse therapeutic approaches into nanomaterials is the key to the development of multimodal synergistic cancer therapy. In this work, tadpole-like carbon nanotubes with Fe nanoparticle encapsulated at the head and Zn single-atom anchored on the body (Fe@CNT-Zn) is precisely designed and facilely prepared via one-pot carbonization. In vitro studies revealed the integration of chemotherapy (CT), chemodynamic therapy (CDT), photothermal therapy (PTT), and photodynamic therapy (PDT) in Fe@CNT-Zn as well as the near-infrared light (NIR)-responsive cascade therapeutic efficacy. Furthermore, in vivo studies demonstrated the NIR-triggered cascade-amplifying synergistic cancer therapy in a B16 tumor-bearing mouse model. The results not only showcased the Fe@CNT-Zn as a potential tetramodal therapeutic platform, but also demonstrated a proof-of-concept on metal-organic framework-based "one stone for multiple birds" strategy for in situ functionalization of carbon materials.
Keyphrases
- cancer therapy
- metal organic framework
- carbon nanotubes
- photodynamic therapy
- drug delivery
- heavy metals
- mouse model
- fluorescence imaging
- drug release
- molecular dynamics
- computed tomography
- sewage sludge
- squamous cell carcinoma
- risk assessment
- aqueous solution
- case control
- fluorescent probe
- optic nerve
- pain management
- radiation therapy
- climate change
- mesenchymal stem cells
- locally advanced
- contrast enhanced