Early detection of amyloid-related changes in memory among cognitively unimpaired older adults with daily digital testing.

Very early Aβ-related memory declines can be revealed by assessing learning over days, suggesting that failures in memory consolidation predate other conventional amnestic deficits in AD. Repeated digital memory assessments, increasingly feasible and uniquely able to assess memory consolidation over short time periods, have the potential to be transformative for detecting the earliest cognitive changes in preclinical AD. This article is protected by copyright. All rights reserved.