Recent Advances in the Oxone-Mediated Synthesis of Heterocyclic Compounds.
Helen A GoulartDaniela R AraujoFilipe PenteadoRaquel G JacobGelson PerinEder Joao LenardaoPublished in: Molecules (Basel, Switzerland) (2021)
Oxone is a commercially available oxidant, composed of a mixture of three inorganic species, being the potassium peroxymonosulfate (KHSO 5 ) the reactive one. Over the past few decades, this cheap and environmentally friendly oxidant has become a powerful tool in organic synthesis, being extensively employed to mediate the construction of a plethora of important compounds. This review summarizes the recent advances in the Oxone-mediated synthesis of N-, O- and chalcogen-containing heterocyclic compounds, through a wide diversity of reactions, starting from several kinds of substrate, highlighting the main synthetic differences, advantages, the scope and limitations.
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