Activated Protein Phosphatase 2A Disrupts Nutrient Sensing Balance Between Mechanistic Target of Rapamycin Complex 1 and Adenosine Monophosphate-Activated Protein Kinase, Causing Sarcopenia in Alcohol-Associated Liver Disease.
Gangarao DavuluriNicole WelchJinendiran SekarMahesha GangadhariahKhaled Alsabbagh AlchiraziMaradumane L MohanAvinash KumarSashi KantSamjhana ThapaliyaMcKenzie StineMegan R McMullenRebecca L McCulloughGeorge R StarkLaura E NagySathyamangla V Naga PrasadSrinivasan DasarathyPublished in: Hepatology (Baltimore, Md.) (2021)
Our study describes the mechanistic underpinnings for ethanol-mediated dysregulation of protein homeostasis by PP2A that leads to sarcopenia with a potential for therapeutic approaches by targeting the PI3Kγ-PP2A axis.