Peripheral microvascular function is linked to cardiac involvement on CMR in systemic sclerosis-related pulmonary arterial hypertension.
Jacqueline L VosJacqueline M J LemmersSaloua El MessaoudiMiranda SnoerenArie P J van DijkAnthonie L DuijnhouwerLaura RodwellSander I van LeuvenMartijn C PostMadelon C VonkRobin NijveldtPublished in: European heart journal. Cardiovascular Imaging (2024)
SSc-PAH patients showed higher markers of cardiac fibrosis and inflammation, compared to IPAH patients. These markers correlated well with peripheral microvascular dysfunction, suggesting that SSc-driven inflammation and vasculopathy concurrently affect peripheral microcirculation and the heart. This may contribute to the disproportionate high mortality in SSc-PAH.
Keyphrases
- systemic sclerosis
- pulmonary arterial hypertension
- end stage renal disease
- oxidative stress
- ejection fraction
- chronic kidney disease
- newly diagnosed
- heart failure
- left ventricular
- interstitial lung disease
- type diabetes
- pulmonary hypertension
- pulmonary artery
- cardiovascular disease
- rheumatoid arthritis
- risk factors
- patient reported