Regioselective Copper-Catalyzed Boracarboxylation of Vinyl Arenes.
Trevor W ButcherEdward J McClainTyler G HamiltonTrina M PerroneKayla M KronerGregory C DonohoeNovruz G AkhmedovJeffrey L PetersenBrian V PoppPublished in: Organic letters (2016)
Regioselective copper-catalyzed boracarboxylation of vinyl arenes with bis(pinacolato)diboron and carbon dioxide has been achieved. New boron-functionalized α-aryl carboxylic acids, including nonsteroidal anti-inflammatory drugs (NSAIDs), are obtained in moderate to excellent yields. The synthetic utility of the transformation was shown through subsequent derivatization of the carbon-boron bond yielding formal hydroxy- and fluorocarboxylation products as well as anionic difluoroboralactones.
Keyphrases
- anti inflammatory drugs
- carbon dioxide
- ms ms
- liquid chromatography tandem mass spectrometry
- high performance liquid chromatography
- gas chromatography mass spectrometry
- high intensity
- ionic liquid
- quantum dots
- simultaneous determination
- liquid chromatography
- tandem mass spectrometry
- ultra high performance liquid chromatography
- transition metal