Analysis of circulating extracellular vesicle derived microRNAs in breast cancer patients with obesity: a potential role for Let-7a.

Ines BaroneLuca GelsominoFelice Maria AccattatisFrancesca GiordanoBalazs GyorffySalvatore PanzaMario GiulianoBianca Maria VenezianiGrazia ArpinoCarmine De AngelisPietro De PlacidoDaniela BonofiglioSebastiano AndòCinzia GiordanoStefania Catalano

Published in: Journal of translational medicine (2023)

These results suggest that serum-EV derived miRNAs may reflect a differential profile in relation to a patient's BMI, which, once validated in larger cohorts of patients, could provide insights into novel specific biomarkers and innovative targets to prevent the progression of obesity-mediated breast cancer.

Keyphrases

insulin resistance
weight gain
metabolic syndrome
end stage renal disease
weight loss
type diabetes
ejection fraction
high fat diet induced
chronic kidney disease
peritoneal dialysis
body mass index
prognostic factors
adipose tissue
patient reported outcomes
physical activity
patient reported