Rare Variants in LRP4 Are Associated with Mesiodens, Root Maldevelopment, and Oral Exostoses in Humans.

Piranit Nik Kantaputra Peeranat Jatooratthawichot Ploy AdisornkanjPanita KitsadayurachMassupa KaewgahyaBjorn OlsenAtsushi OhazamaChumpol NgamphiwSissades TongsimaTimothy C Cox James R Ketudat Cairns

Published in: Biology (2023)

as contributing factors in the presentation of mesiodens, root maldevelopments, and oral exostoses, possibly as a result of altered WNT/β-catenin-BMP-SHH signaling.

Keyphrases

cell proliferation
stem cells
mesenchymal stem cells
epithelial mesenchymal transition
copy number
case report
gene expression
dna methylation
signaling pathway