Organic CO Prodrugs Activated by Endogenous ROS.

Zhixiang PanJun ZhangKaili JiVayou ChittavongXingyue JiBinghe Wang

Published in: Organic letters (2017)

CO prodrugs with triggered release mechanisms are highly desirable for targeted delivery. Herein described are organic CO prodrugs that are activated by ROS and thus can be used to selectively deliver CO to cells with elevated ROS levels. Such CO prodrugs can serve as powerful tools for targeted delivery to disease sites with elevated ROS levels and to explore the therapeutic applications of CO.

Keyphrases

cell death
dna damage
reactive oxygen species
cell cycle arrest
induced apoptosis
oxidative stress
water soluble
endoplasmic reticulum stress
cell proliferation