A novel role of DOT1L in kidney diseases.

Wei WeiYibo ZhaoYanfen ChaiSongtao ShouHeng Jin

Published in: Molecular biology reports (2023)

A better understanding of DOT1L as a histone methylase based on characteristics of regulating telomere silencing, transcriptional extension, DNA damage repair and cell cycle could lead to the development of new therapeutic targets for various kidney diseases, thereby improving the prognosis of kidney disease patients.

Keyphrases

cell cycle
dna damage
end stage renal disease
ejection fraction
cell proliferation
chronic kidney disease
newly diagnosed
peritoneal dialysis
prognostic factors
gene expression
dna methylation
transcription factor