Combination of Atractylenolide I, Atractylenolide III, and Paeoniflorin promotes angiogenesis and improves neurological recovery in a mouse model of ischemic Stroke.
Haiyan LiWantong YuYong YangSijie LiJun XuChen GaoWei ZhangWenjie ShiKunlin JinXunming JiChanghong RenPublished in: Chinese medicine (2024)
The administration of Atr I, Atr III, and Pae has shown significant enhancements in long-term stroke recovery in mice, likely due to the promotion of angiogenesis via increased activation of the IGF-2 pathway in ischemic brain tissue.
Keyphrases
- cerebral ischemia
- mouse model
- endothelial cells
- atrial fibrillation
- vascular endothelial growth factor
- dna damage response
- wound healing
- subarachnoid hemorrhage
- white matter
- high fat diet induced
- resting state
- blood brain barrier
- binding protein
- ischemia reperfusion injury
- oxidative stress
- insulin resistance
- dna damage
- signaling pathway
- dna repair