Role of T and B lymphocyte cannabinoid type 1 and 2 receptors in major depression and suicidal behaviors.

Michael MaesMuanpetch RachayonKetsupar JirakranAtapol SughondhabiromAbbas F AlmullaPimpayao Sodsai

Published in: Acta neuropsychiatrica (2023)

reductions in FoxP3+CB1+% and CD3+/CD4+CB2+% contribute to deficits in immune homeostasis in MDD, while increased CD20+CB2+% may contribute to the pathophysiology of MDD by activating T-independent humoral immunity.

Keyphrases

major depressive disorder
immune response
regulatory t cells
traumatic brain injury
depressive symptoms
signaling pathway
peripheral blood