Women Have Greater Endothelin-B Receptor Function and Lower Mitochondrial Capacity Compared to Men with Type 1 Diabetes.

Compared to men with uncomplicated T1D, muscle oxidative capacity was lower and ETBR-mediated vasodilation was higher in women with uncomplicated T1D. ETBR-induced vasodilatory capacity was inversely related to skeletal muscle oxidative capacity, suggesting that there may be compensatory mechanisms occurring to preserve microvascular blood flow in women with T1D.