Pd(II)-Catalyzed Tandem Enantioselective Methylene C(sp3 )-H Alkenylation-Aza-Wacker Cyclization to Access β-Stereogenic γ-Lactams.
Yi DingYe-Qiang HanLe-Song WuTao ZhouQi-Jun YaoYa-Lan FengYa LiKe-Xin KongTimothy M SwagerPublished in: Angewandte Chemie (International ed. in English) (2020)
Herein, we describe an unprecedented cascade reaction to β-stereogenic γ-lactams involving Pd(II)-catalyzed enantioselective aliphatic methylene C(sp3 )-H alkenylation-aza-Wacker cyclization through syn-aminopalladation. Readily available 3,3'-substituted BINOLs are used as chiral ligands, providing the corresponding γ-lactams with broad scope and high enantioselectivities (up to 98 % ee).
Keyphrases