Generational synaptic functions of GABA A receptor β3 subunit deteriorations in an animal model of social deficit.
Ming-Chia ChuHan-Fang WuChi-Wei LeeYueh-Jung ChungHsiang ChiPo See ChenHui Ching LinPublished in: Journal of biomedical science (2022)
Taken together, these findings revealed the E/I synaptic abnormalities in the amygdala from two generations of the VPA-induced offspring with GABAergic deteriorations in the F2 generation, suggesting a potential therapeutic role of the GABAergic system to generational pathophysiology of ASD.
Keyphrases
- prefrontal cortex
- autism spectrum disorder
- high glucose
- diabetic rats
- healthcare
- functional connectivity
- mental health
- high fat diet
- attention deficit hyperactivity disorder
- single cell
- drug induced
- intellectual disability
- type diabetes
- oxidative stress
- adipose tissue
- skeletal muscle
- binding protein
- working memory
- temporal lobe epilepsy