Obesity impacts the regulation of miR-10b and its targets in primary breast tumors.
Ari MeersonYaniv ElirazHila YehudaBridget KnightMalcolm CrundwellDouglas FergusonBenjamin P LeeLorna W HarriesPublished in: BMC cancer (2019)
Our findings suggest that miR-10b may be a mediator between obesity and cancer in post-menopausal women, regulating several known cancer-relevant genes. MiR-10b expression may have diagnostic and therapeutic implications for the incidence and prognosis of BC in obese women.
Keyphrases
- weight loss
- metabolic syndrome
- papillary thyroid
- insulin resistance
- polycystic ovary syndrome
- type diabetes
- squamous cell
- high fat diet induced
- adipose tissue
- pregnancy outcomes
- bariatric surgery
- risk factors
- squamous cell carcinoma
- lymph node metastasis
- gene expression
- pregnant women
- young adults
- obese patients
- body mass index
- dna methylation
- long non coding rna
- bioinformatics analysis