Downregulation of Lysosome-Associated Membrane Protein-2A Contributes to the Pathogenesis of COPD.
Yun-Jeong JeongKyoung-Hee LeeJisu WooJi Yeon KimChang Hoon LeeChul Gyu YooPublished in: International journal of chronic obstructive pulmonary disease (2023)
Cigarette smoke-induced down-regulation of LAMP-2A is involved in acceleration of aging and apoptosis of lung epithelial cells, which might at least partially contribute to COPD pathogenesis.
Keyphrases
- chronic obstructive pulmonary disease
- lung function
- oxidative stress
- diabetic rats
- high glucose
- endoplasmic reticulum stress
- cell death
- cell cycle arrest
- cell proliferation
- fluorescent probe
- signaling pathway
- drug induced
- loop mediated isothermal amplification
- living cells
- air pollution
- endothelial cells
- sensitive detection