Enhanced cAMP-stimulated protein kinase A activity in human fibrolamellar hepatocellular carcinoma.

Kevin M RiggleKimberly J RiehleHeidi L KenersonRigney TurnhamMiwako Kato HommaMachiko KazamiBret SamelsonRenay BauerG Stanley McKnightJohn D ScottRaymond S Yeung

Published in: Pediatric research (2016)

FL-HCCs in children and young adults uniquely overexpress DNAJB1-PRKACA, which results in elevated cAMP-dependent PKA activity. These data suggest that aberrant PKA signaling contributes to liver tumorigenesis.

Keyphrases

young adults
protein kinase
endothelial cells
binding protein
electronic health record
big data
machine learning
childhood cancer
artificial intelligence
deep learning