Predicting probability of tolerating discrete amounts of peanut protein in allergic children using epitope-specific IgE antibody profiling.
Maria SuprunPaul KearneyClive HaywardHeather ButlerRobert GettsScott Howard SichererPaul J TurnerDianne E CampbellHugh A SampsonPublished in: Allergy (2022)
Accurate predictions of food challenge thresholds are complex due to factors including limited responder sample sizes at each dose and variations in study-specific challenge protocols. Despite these limitations, an epitope-based predictor was able to accurately identify CTDs and may provide a useful surrogate for peanut challenges.