Impact of RBE variations on risk estimates of temporal lobe necrosis in patients treated with intensity-modulated proton therapy for head and neck cancer.
Grete May EngesethLiv Bolstad HysingPablo YepesHelge Egil Seime PettersenRadhe MohanClifton Dave FullerCamilla Hanquist StokkevågRichard WuXiaodong ZhangSteven Jay FrankGary Brandon GunnPublished in: Acta oncologica (Stockholm, Sweden) (2021)
NTCP estimates were significantly influenced by RBE variations. Dmax as model predictor resulted in the largest deviations in risk estimates between RWDFix and RWDVar. V65GyRBE ≤ 0.03 cc was the most consistent dose constraint for RWDFix and RWDVar.
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