Myeloid cell deletion of Aryl hydrocarbon Receptor Nuclear Translocator (ARNT) induces non-alcoholic steatohepatitis.

Christopher ScottRebecca StokesKuan Minn ChaAndrew CloustonMohammed EslamMayda MetwallyMichael M SwarbrickJacob GeorgeJenny E Gunton

Published in: PloS one (2019)

Decreased myeloid ARNT may play a role in the conversion from non-alcoholic fatty liver to steatohepatitis. Increasing ARNT may be a therapeutic strategy to reduce NASH.

Keyphrases

liver injury
dendritic cells
bone marrow
acute myeloid leukemia
single cell
drug induced
cell therapy
liver fibrosis
stem cells
mesenchymal stem cells
binding protein