Brain MRS correlates with mitochondrial dysfunction biomarkers in MELAS-associated mtDNA mutations.
Laura Ludovica GramegnaStefania EvangelistiLidia Di VitoChiara La MorgiaAlessandra MarescaLeonardo CaporaliGiulia AmoreLia TalozziClaudio BianchiniClaudia TestaDavid N MannersIrene CortesiMaria L ValentinoRocco LiguoriValerio CarelliCaterina TononRaffaele LodiPublished in: Annals of clinical and translational neurology (2021)
Correlations were found between the peripheral and biochemical markers of mitochondrial dysfunction and brain in vivo markers of neurodegeneration, supporting the use of both biomarkers as signatures of MELAS and MSS disease, to evaluate the efficacy of potential treatments.