Utilizing a nanocomposite aerogel grafted with Fe 3 O 4 @GO for the extraction and determination of metoprolol in exhaled breath condensate.
Bita AzadZahra KarimzadehAmirreza JabbaripourVahid Jouyban-GharamalekiMaryam KhoubnasabjafariAbolghasem JouybanAlireza ForoumadiPublished in: RSC advances (2023)
This article presents a solid-phase extraction method combined with a spectrofluorometric method for the extraction/pre-concentration and determination of metoprolol (MET) in exhaled breath condensate. The extraction sorbent is an agarose aerogel nanocomposite grafted with graphene oxide (GO) Fe 3 O 4 . The size and morphology of the nanosorbent were characterized via X-ray crystallography, scanning electron microscopy, Fourier-transform infrared spectrometry, and Brunauer-Emmett-Teller analysis. Factors affecting the extraction/determination of MET were optimized using the one-at-a-time method. Under optimized experimental conditions, the calibration graph was linear in the range of 0.005 to 2.0 μg mL -1 with a detection limit of 0.001 μg mL -1 . The method was successfully applied for the determination of MET in biological samples taken from patients receiving MET.
Keyphrases
- solid phase extraction
- molecularly imprinted
- high performance liquid chromatography
- liquid chromatography tandem mass spectrometry
- electron microscopy
- tandem mass spectrometry
- gas chromatography mass spectrometry
- simultaneous determination
- liquid chromatography
- ultra high performance liquid chromatography
- tyrosine kinase
- gas chromatography
- high resolution
- magnetic resonance
- machine learning
- magnetic resonance imaging
- gold nanoparticles
- ms ms
- neural network
- dual energy
- quantum dots