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3-D printing of chitosan-calcium phosphate inks: rheology, interactions and characterization.

Silvia Stella Ramirez CaballeroEduardo SaizAlexandra MontembaultSolène TadierEric MaireLaurent DavidThierry DelairLaurent Gremillard
Published in: Journal of materials science. Materials in medicine (2018)
Bone substitute fabrication is of interest to meet the worldwide incidence of bone disorders. Physical chitosan hydrogels with intertwined apatite particles were chosen to meet the bio-physical and mechanical properties required by a potential bone substitute. A set up for 3-D printing by robocasting was found adequate to fabricate scaffolds. Inks consisted of suspensions of calcium phosphate particles in chitosan acidic aqueous solution. The inks are shear-thinning and consist of a suspension of dispersed platelet aggregates of dicalcium phosphate dihydrate in a continuous chitosan phase. The rheological properties of the inks were studied, including their shear-thinning characteristics and yield stress. Scaffolds were printed in basic water/ethanol baths to induce transformation of chitosan-calcium phosphates suspension into physical hydrogel of chitosan mineralized with apatite. Scaffolds consisted of a chitosan polymeric matrix intertwined with poorly crystalline apatite particles. Results indicate that ink rheological properties could be tuned by controlling ink composition: in particular, more printable inks are obtained with higher chitosan concentration (0.19 mol·L-1).
Keyphrases
  • drug delivery
  • wound healing
  • hyaluronic acid
  • cancer therapy
  • tissue engineering
  • physical activity
  • soft tissue
  • risk factors
  • risk assessment
  • climate change