Ertapenem plus meropenem combination treatment in carbapenem-resistant Klebsiella pneumoniae bacteremia: an analysis of 53 cases.
Uğur ÖnalDeniz AkyolArda KayaDilşah BaşkolBuse KenanogluGamze ŞanlıdağAyşe Uyan ÖnalCansu Bulut AvşarMerve MertSeichan MemetaliHüseyin Aytaç ErdemDevrim BozkurtAdnan ŞimşirOsman BozbıyıkÜmit KahramanErkin ÖzgirayPervin KorkmazFeriha ÇilliHüsnü PullukçuTansu YamazhanMeltem Işıkgöz TaşbakanBilgin ArdaSercan UlusoyOğuz Reşat SipahiPublished in: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology (2023)
Herein, we aimed to describe the outcomes of patients with blood stream infections due to carbapenem-resistant Klebsiella pneumoniae (CR-Kp) who received ertapenem plus meropenem combination treatment (EMCT). A total of 53 patients with culture proven CR-Kp bacteremia treated with ertapenem + meropenem were included. The patients with secondary bacteremia due to urinary tract infection exhibited a significantly lower 1-month mortality (OMM), particularly in those with microbiological eradication and those with end-of-treatment success. Salvage EMCT resulted in 49% 1-month survival.