Cytotoxic Tigliane Diterpenoids from Croton damayeshu.

Jiao-Jiao CuiKai-Long JiHong-Chun LiuBin ZhouQun-Fang LiuCheng-Hui XuJian DingJin-Xin Zhao Jian-Min Yue

Published in: Journal of natural products (2019)

Chemical investigation of an EtOH extract of the twigs and leaves of Croton damayeshu afforded 10 new tigliane diterpenoids, crodamoids A-J (1-10), along with five known compounds. Their structures were elucidated by physical data analysis. Compounds 8, 9, and 15 displayed cytotoxic effects against two human tumor cell lines, A549 and HL-60 (IC50: 0.9-2.4 μM).

Keyphrases

data analysis
endothelial cells
physical activity
mental health
induced pluripotent stem cells
high resolution
essential oil